abstract：BACKGROUND:The global burden of cholera is largely unknown because the majority of cases are not reported. The low reporting can be attributed to limited capacity of epidemiological surveillance and laboratories, as well as social, political, and economic disincentives for reporting. We previously estimated 2.8 million...

journal_title：PLoS neglected tropical diseases

authors： Ali M,Nelson AR,Lopez AL,Sack DA

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:Vector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and vector control, however, much less is known about the burden of ...

journal_title：PLoS neglected tropical diseases

authors： Alroy KA,Huang C,Gilman RH,Quispe-Machaca VR,Marks MA,Ancca-Juarez J,Hillyard M,Verastegui M,Sanchez G,Cabrera L,Vidal E,Billig EM,Cama VA,Náquira C,Bern C,Levy MZ,Working Group on Chagas Disease in Peru.

更新日期：2015-05-22 00:00:00

abstract：:Mosquito-borne diseases continue to remain major threats to human and animal health and impediments to socioeconomic development. Increasing mosquito resistance to chemical insecticides is a great public health concern, and new strategies/technologies are necessary to develop the next-generation of vector control tool...

journal_title：PLoS neglected tropical diseases

authors： Phanse Y,Dunphy BM,Perry JL,Airs PM,Paquette CC,Carlson JO,Xu J,Luft JC,DeSimone JM,Beaty BJ,Bartholomay LC

更新日期：2015-05-21 00:00:00

abstract：:Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirmed and an investigation was conducted to estimate the magnitude of local transmi...

journal_title：PLoS neglected tropical diseases

authors： Ellis EM,Neatherlin JC,Delorey M,Ochieng M,Mohamed AH,Mogeni DO,Hunsperger E,Patta S,Gikunju S,Waiboic L,Fields B,Ofula V,Konongoi SL,Torres-Velasquez B,Marano N,Sang R,Margolis HS,Montgomery JM,Tomashek KM

更新日期：2015-04-29 00:00:00

abstract：INTRODUCTION:Between 1998 and 2010, S. Typhi was an uncommon cause of bloodstream infection (BSI) in Blantyre, Malawi and it was usually susceptible to first-line antimicrobial therapy. In 2011 an increase in a multidrug resistant (MDR) strain was detected through routine bacteriological surveillance conducted at Queen...

journal_title：PLoS neglected tropical diseases

authors： Feasey NA,Gaskell K,Wong V,Msefula C,Selemani G,Kumwenda S,Allain TJ,Mallewa J,Kennedy N,Bennett A,Nyirongo JO,Nyondo PA,Zulu MD,Parkhill J,Dougan G,Gordon MA,Heyderman RS

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:Opisthorchis felineus, O. viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose a serious threat to humans in some countries and cause opisthorchiasis/clonorchiasis. Chronic disease may lead to a risk of carcinogenesis in the biliary ducts. MicroRNAs (miRNAs) are small...

journal_title：PLoS neglected tropical diseases

authors： Ovchinnikov VY,Afonnikov DA,Vasiliev GV,Kashina EV,Sripa B,Mordvinov VA,Katokhin AV

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Trypanosomiasis induces a remarkable myenteric neuronal degeneration leading to megacolon. Very little is known about the risk for colon cancer in chagasic megacolon patients. To clarify whether chagasic megacolon impacts on colon carcinogenesis, we investigated the risk for colon cancer in Trypanosoma cruzi...

journal_title：PLoS neglected tropical diseases

authors： Kannen V,de Oliveira EC,Motta BZ,Chaguri AJ,Brunaldi MO,Garcia SB

更新日期：2015-04-17 00:00:00

abstract：:The current outbreak of Ebola Virus Disease in Upper West Africa is the largest ever recorded. Molecular evidence suggests spread has been almost exclusively through human-to-human contact. Social factors are thus clearly important to understand the epidemic and ways in which it might be stopped, but these factors hav...

journal_title：PLoS neglected tropical diseases

authors： Richards P,Amara J,Ferme MC,Kamara P,Mokuwa E,Sheriff AI,Suluku R,Voors M

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition of sirtuins ...

journal_title：PLoS neglected tropical diseases

authors： Ritagliati C,Alonso VL,Manarin R,Cribb P,Serra EC

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Although antibody responses to dengue virus (DENV) in naturally infected individuals have been extensively studied, the functionality of DENV specific memory T cell responses in relation to clinical disease severity is incompletely understood. METHODOLOGY/PRINCIPAL FINDINGS:Using ex vivo IFNγ ELISpot assays...

journal_title：PLoS neglected tropical diseases

authors： Jeewandara C,Adikari TN,Gomes L,Fernando S,Fernando RH,Perera MK,Ariyaratne D,Kamaladasa A,Salimi M,Prathapan S,Ogg GS,Malavige GN

更新日期：2015-04-13 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Mosquito-borne pathogens pose major public health challenges worldwide. With vaccines or effective drugs still unavailable for most such pathogens, disease prevention heavily relies on vector control. To date, however, mosquito control has proven difficult, with low breeding-site coverage during control camp...

journal_title：PLoS neglected tropical diseases

authors： Abad-Franch F,Zamora-Perea E,Ferraz G,Padilla-Torres SD,Luz SL

更新日期：2015-04-07 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the parenteral administration route of most of them, are si...

journal_title：PLoS neglected tropical diseases

authors： Calvo-Álvarez E,Stamatakis K,Punzón C,Álvarez-Velilla R,Tejería A,Escudero-Martínez JM,Pérez-Pertejo Y,Fresno M,Balaña-Fouce R,Reguera RM

更新日期：2015-03-31 00:00:00

abstract：:Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic proteins act as bio-markers for the detec...

journal_title：PLoS neglected tropical diseases

authors： Nandi SK,Chakraborty A,Panda AK,Ray SS,Kar RK,Bhunia A,Biswas A

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:In 2010 and 2011, Haiti was heavily affected by a large cholera outbreak that spread throughout the country. Although national health structure-based cholera surveillance was rapidly initiated, a substantial number of community cases might have been missed, particularly in remote areas. We conducted a commun...

journal_title：PLoS neglected tropical diseases

authors： Page AL,Ciglenecki I,Jasmin ER,Desvignes L,Grandesso F,Polonsky J,Nicholas S,Alberti KP,Porten K,Luquero FJ

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin ...

journal_title：PLoS neglected tropical diseases

authors： Antony JS,Ojurongbe O,Kremsner PG,Velavan TP

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particula...

journal_title：PLoS neglected tropical diseases

authors： Nausch N,Appleby LJ,Sparks AM,Midzi N,Mduluza T,Mutapi F

更新日期：2015-03-23 00:00:00

abstract：BACKGROUND:American visceral leishmaniasis (AVL) is an emerging disease in the state of São Paulo, Brazil. Its geographical expansion and the increase in the number of human cases has been linked to dispersion of Lutzomyia longipalpis into urban areas. To produce more accurate risk maps we investigated the geographic d...

journal_title：PLoS neglected tropical diseases

authors： Casanova C,Colla-Jacques FE,Hamilton JG,Brazil RP,Shaw JJ

更新日期：2015-03-17 00:00:00

abstract：:Plasmodium vivax, one of the five species of Plasmodium parasites that cause human malaria, is responsible for 25-40% of malaria cases worldwide. Malaria global elimination efforts will benefit from accurate and effective genotyping tools that will provide insight into the population genetics and diversity of this par...

journal_title：PLoS neglected tropical diseases

authors： Baniecki ML,Faust AL,Schaffner SF,Park DJ,Galinsky K,Daniels RF,Hamilton E,Ferreira MU,Karunaweera ND,Serre D,Zimmerman PA,Sá JM,Wellems TE,Musset L,Legrand E,Melnikov A,Neafsey DE,Volkman SK,Wirth DF,Sabeti PC

更新日期：2015-03-17 00:00:00

abstract：:Mycetoma is a unique neglected tropical disease which is endemic in what is known as the "mycetoma belt". The disease has many devastating impacts on patients and communities in endemic area and is characterised by massive deformity, destruction and disability. Mycetoma is commonly seen in the foot and hand and less f...

journal_title：PLoS neglected tropical diseases

authors： Fahal A,Mahgoub el S,El Hassan AM,Jacoub AO,Hassan D

更新日期：2015-03-13 00:00:00

abstract：:Humoral immunity plays an important role in controlling dengue virus (DENV) infection. Antibodies (Abs) developed during primary infection protect against subsequent infection with the same dengue serotype, but can enhance disease following secondary infection with a heterologous serotype. A DENV virion has two surfac...

journal_title：PLoS neglected tropical diseases

authors： Rodenhuis-Zybert IA,da Silva Voorham JM,Torres S,van de Pol D,Smit JM

更新日期：2015-03-11 00:00:00

abstract：:Diarrheagenic Escherichia coli (DEC) cause acute and persistent diarrhoea worldwide, but little is known about their epidemiology in Mexico. We determined the prevalence of bacterial enteropathogens in 831 children with acute diarrhoea over a four-year period in Yucatan, Mexico. Six DEC supplementary virulence genes (...

journal_title：PLoS neglected tropical diseases

authors： Patzi-Vargas S,Zaidi MB,Perez-Martinez I,León-Cen M,Michel-Ayala A,Chaussabel D,Estrada-Garcia T

更新日期：2015-03-04 00:00:00

abstract：:Chikungunya virus (CHIKV) is the only causative agent of CHIKV fever with persistent arthralgia, and in some cases may lead to neurological complications which can be highly fatal, therefore it poses severe health issues in many parts of the world. CHIKV transmission can be mediated via the Aedes albopictus mosquito; ...

journal_title：PLoS neglected tropical diseases

authors： Lee RC,Chu JJ

更新日期：2015-03-04 00:00:00

abstract：:Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C...

journal_title：PLoS neglected tropical diseases

authors： Huang L,Hinchman M,Mendez S

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:In the late twentieth century, emergence of high rates of treatment failure with antimonial compounds (SSG) for visceral leishmaniasis (VL) caused a public health crisis in Bihar, India. We hypothesize that exposure to arsenic through drinking contaminated groundwater may be associated with SSG treatment fai...

journal_title：PLoS neglected tropical diseases

authors： Perry MR,Prajapati VK,Menten J,Raab A,Feldmann J,Chakraborti D,Sundar S,Fairlamb AH,Boelaert M,Picado A

更新日期：2015-03-02 00:00:00

abstract：BACKGROUND:Few studies have assessed the burden of Chagas disease in non-endemic countries and most of them are based on prevalence estimates from Latin American (LA) countries that likely differ from the prevalence in migrants living in Europe. The aim of this study was to systematically review the existing data infor...

journal_title：PLoS neglected tropical diseases

authors： Requena-Méndez A,Aldasoro E,de Lazzari E,Sicuri E,Brown M,Moore DA,Gascon J,Muñoz J

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected patients who should be carefully monitored to exclude the persistence of the infection. In a previous study, we demonstrated high accuracy of five ser...

journal_title：PLoS neglected tropical diseases

authors： Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Degani M,Tais S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB,Bisoffi Z

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND:Hantaan virus (HTNV) causes a severe lethal haemorrhagic fever with renal syndrome (HFRS) in humans. Despite a limited understanding of the pathogenesis of HFRS, the importance of the abundant production of pro-inflammatory cytokines has been widely recognized. Interleukin 33 (IL-33) has been demonstrated to...

journal_title：PLoS neglected tropical diseases

authors： Zhang Y,Zhang C,Zhuang R,Ma Y,Zhang Y,Yi J,Yang A,Jin B

更新日期：2015-02-06 00:00:00

abstract：:Although several studies have associated Mycobacterium ulcerans (MU) infection, Buruli ulcer (BU), with slow moving water bodies, there is still no definite mode of transmission. Ecological and transmission studies suggest Variable Number Tandem Repeat (VNTR) typing as a useful tool to differentiate MU strains from ot...

journal_title：PLoS neglected tropical diseases

authors： Narh CA,Mosi L,Quaye C,Dassi C,Konan DO,Tay SC,de Souza DK,Boakye DA,Bonfoh B

更新日期：2015-01-22 00:00:00

abstract：:The complement cascade in mammalian blood can damage the alimentary tract of haematophagous arthropods. As such, these animals have evolved their own repertoire of complement-inactivating factors, which are inadvertently exploited by blood-borne pathogens to escape complement lysis. Unlike the bloodstream stages, the ...

journal_title：PLoS neglected tropical diseases

authors： Ooi CP,Haines LR,Southern DM,Lehane MJ,Acosta-Serrano A

更新日期：2015-01-08 00:00:00

abstract：:Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 responses could be related to aggravated pathology in HO. Using flow cytome...

journal_title：PLoS neglected tropical diseases

authors： Katawa G,Layland LE,Debrah AY,von Horn C,Batsa L,Kwarteng A,Arriens S,W Taylor D,Specht S,Hoerauf A,Adjobimey T

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Entomological indicators are considered key metrics to document the interruption of transmission of Onchocerca volvulus, the etiological agent of human onchocerciasis. Human landing collection is the standard employed for collection of the vectors for this parasite. Recent studies reported the development of...

journal_title：PLoS neglected tropical diseases

authors： Young RM,Burkett-Cadena ND,McGaha TW Jr,Rodriguez-Perez MA,Toé LD,Adeleke MA,Sanfo M,Soungalo T,Katholi CR,Noblet R,Fadamiro H,Torres-Estrada JL,Salinas-Carmona MC,Baker B,Unnasch TR,Cupp EW

更新日期：2015-01-08 00:00:00

abstract：:Mycobacterium africanum is a member of the Mycobacterium tuberculosis complex (MTBC) and an important cause of human tuberculosis in West Africa that is rarely observed elsewhere. Here we genotyped 613 MTBC clinical isolates from Ghana, and searched for associations between the different phylogenetic lineages of MTBC ...

journal_title：PLoS neglected tropical diseases

authors： Asante-Poku A,Yeboah-Manu D,Otchere ID,Aboagye SY,Stucki D,Hattendorf J,Borrell S,Feldmann J,Danso E,Gagneux S

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Most commonly used malaria diagnostic tests, including microscopy and antigen-detecting rapid tests, cannot reliably detect low-density infections which are frequent in low transmission settings. Molecular methods such as polymerase chain reaction (PCR) are highly sensitive but remain too laborious for field...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Martínez NL,González IJ,Arévalo-Herrera M,Herrera S

更新日期：2015-01-08 00:00:00

abstract：:Burkholderia pseudomallei, the bacterial agent of melioidosis, causes disease through inhalation of infectious particles, and is classified as a Tier 1 Select Agent. Optical diagnostic imaging has demonstrated that murine respiratory disease models are subject to significant upper respiratory tract (URT) colonization....

journal_title：PLoS neglected tropical diseases

authors： Gutierrez MG,Pfeffer TL,Warawa JM

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Diagnosis of human African trypanosomiasis (HAT) remains a challenge both for active screening, which is critical in control of the disease, and in the point-of-care scenario where early and accurate diagnosis is essential. Recently, the first field deployment of a lateral flow rapid diagnostic test (RDT) fo...

journal_title：PLoS neglected tropical diseases

authors： Sternberg JM,Gierliński M,Biéler S,Ferguson MA,Ndung'u JM

更新日期：2014-12-18 00:00:00

abstract：BACKGROUND:Venom recurrence or persistence in the circulation after antivenom treatment has been documented many times in viper envenoming. However, it has not been associated with clinical recurrence for many snakes, including Russell's viper (Daboia spp.). We compare the recovery of coagulopathy to the recurrence or ...

journal_title：PLoS neglected tropical diseases

authors： Maduwage K,O'Leary MA,Scorgie FE,Shahmy S,Mohamed F,Abeysinghe C,Karunathilake H,Lincz LF,Gnanathasan CA,Isbister GK

更新日期：2014-12-18 00:00:00

abstract：:Leprosy is a curable neglected disease of humans caused by Mycobacterium leprae that affects the skin and peripheral nerves and manifests clinically in various forms ranging from self-resolving, tuberculoid leprosy to lepromatous leprosy having significant pathology with ensuing disfiguration disability and social sti...

journal_title：PLoS neglected tropical diseases

authors： Wheat WH,Casali AL,Thomas V,Spencer JS,Lahiri R,Williams DL,McDonnell GE,Gonzalez-Juarrero M,Brennan PJ,Jackson M

更新日期：2014-12-18 00:00:00

abstract：BACKGROUND:Carrion' disease, caused by Bartonella bacilliformis, remains truly neglected due to its focal geographical nature. A wide spectrum of clinical manifestations, including asymptomatic bacteremia, and lack of a sensitive diagnostic test can potentially lead to a spread of the disease into non-endemic regions w...

journal_title：PLoS neglected tropical diseases

authors： Angkasekwinai N,Atkins EH,Johnson RN,Grieco JP,Ching WM,Chao CC

更新日期：2014-12-18 00:00:00

abstract：BACKGROUND:The Norway rat (Rattus norvegicus) is the principal reservoir for leptospirosis in many urban settings. Few studies have identified markers for rat infestation in slum environments while none have evaluated the association between household rat infestation and Leptospira infection in humans or the use of inf...

journal_title：PLoS neglected tropical diseases

authors： Costa F,Ribeiro GS,Felzemburgh RD,Santos N,Reis RB,Santos AC,Fraga DB,Araujo WN,Santana C,Childs JE,Reis MG,Ko AI

更新日期：2014-12-04 00:00:00